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The proinflammatory phenotype may be the dominant phenotype of immune cells in T2DM. In T2DM, M1 macrophages are classified as the dominant immune cells that result in inflammation in islets.352,353,354 The expression amounts of PPARγ in macrophages from T2DM sufferers are reduced, and macrophage-specific PPARγ controls M2 macrophage activation.3